Salvianolic acid B reduced the formation of epidural fibrosis in an experimental rat model
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Salvianolic acid B reduced the formation of epidural fibrosis in an experimental rat model
BACKGROUND Salvianolic acid B (Sal B) was newly reported to be able to attenuate fibrosis in the animal model. The aim of the present study was to investigate the effect of the intragastric application of Sal B on the prevention of epidural fibrosis (EF). METHODS Forty healthy adult male Wistar rats were divided into four treatment groups (n = 10 per group): (1) 10 mg/kg Sal B, (2) 30 mg/kg S...
متن کاملStudy on salvianolic acid B in the reduction of epidural fibrosis in laminectomy rats
BACKGROUND Epidural fibrosis (EF) is a common complication after laminectomy. Salvianolic acid B (Sal B) is a major bioactive component of a traditional Chinese medical agent, Salvia miltiorrhiza, which has shown anti-inflammatory, anti-fibrotic and anti-proliferative properties. The object of this study was to investigate the effect of Sal B on the prevention of epidural fibrosis in laminectom...
متن کاملEffect of Etanercept on the Formation of Epidural Fibrosis in an Experimental Model.
AIM To investigate the effects of local and systemic administration of etanercept on the formation of epidural fibrosis. MATERIAL AND METHODS Twenty-eight rats were randomly divided into four equal groups (Control, SpongostanTM, Local etanercept and Systemic etanercept) and laminectomy was performed between T11 and L1 in all rats. SpongostanTM was soaked with saline (0.1 mg/kg), local etanerc...
متن کاملSalvianolic Acid B Attenuates Experimental Pulmonary Fibrosis through Inhibition of the TGF-β Signaling Pathway
Pulmonary fibrosis is a progressive and fatal disorder. In our previous study, we found that the Yiqihuoxue formula (YQHX), a prescription of Traditional Chinese Medicine, had a curative effect on scleroderma, a typical fibrotic disease. The aim of this study was to determine the key ingredient mediating the therapeutic effects of YQHX and to examine its effect on pulmonary fibrosis, including ...
متن کاملAuthor ' s response to reviews Title : Study on Salvianolic acid B in the reduction of epidural fibrosis in laminectomy rats
2 Background: Epidural fibrosis (EF) is a common complication after laminectomy. Salvianolic acid B (Sal B) is a major bioactive component of a traditional Chinese medical agent, Salvia miltiorrhiza, which has shown anti-inflammatory, anti-fibrotic and anti-proliferative properties. Objection: The object of this study was to investigate the effect of Sal B on the prevention of epidural fibrosis...
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ژورنال
عنوان ژورنال: Journal of Orthopaedic Surgery and Research
سال: 2016
ISSN: 1749-799X
DOI: 10.1186/s13018-016-0475-x